Activation of heparin cofactor II by dermatan sulfate.
DM Tollefsen, CA Pestka, WJ Monafo - Journal of Biological Chemistry, 1983 - ASBMB
We have tested the ability of various glycosaminoglycans to increase the rate of inhibition of
thrombin by heparin cofactor II (HCII) and by antithrombin III (ATIII) isolated from human
plasma. Heparin, dermatan sulfate, and heparan sulfate from bovine liver (in order of
decreasing activity) activated HCII. In contrast, only heparin and bovine liver heparan sulfate
activated ATIII, whereas dermatan sulfate was inactive at concentrations less than or equal
to 1 mg/ml. Heparan sulfate from human aorta, chondroitin 4-sulfate, chondroitin 6-sulfate …
thrombin by heparin cofactor II (HCII) and by antithrombin III (ATIII) isolated from human
plasma. Heparin, dermatan sulfate, and heparan sulfate from bovine liver (in order of
decreasing activity) activated HCII. In contrast, only heparin and bovine liver heparan sulfate
activated ATIII, whereas dermatan sulfate was inactive at concentrations less than or equal
to 1 mg/ml. Heparan sulfate from human aorta, chondroitin 4-sulfate, chondroitin 6-sulfate …
