Mechanisms of platelet aggregation

B Savage, M Cattaneo, ZM Ruggeri - Current opinion in …, 2001 - journals.lww.com
Current opinion in hematology, 2001journals.lww.com
Platelet aggregation is initiated by receptor activation coupled to intracellular signaling
leading to activation of integrin α IIb β 3. Recent advances in the study of platelet receptors
for collagen, von Willebrand factor, thrombin, and adenosine diphosphate are providing new
insights into the mechanisms of platelet aggregation.
Abstract
Platelet aggregation is initiated by receptor activation coupled to intracellular signaling leading to activation of integrin α IIb β 3. Recent advances in the study of platelet receptors for collagen, von Willebrand factor, thrombin, and adenosine diphosphate are providing new insights into the mechanisms of platelet aggregation.
Lippincott Williams & Wilkins