Molecular identification and expression of erythroid K: Cl cotransporter in human and mouse erythroleukemic cells
CM Pellegrino, AC Rybicki, S Musto, RL Nagel… - Blood cells, molecules …, 1998 - Elsevier
A major pathway for K+ efflux in human reticulocytes and young RBCs is K: Cl cotransport
(K: Cl-CT). The activity of K: Cl-CT is increased in pathologic RBCs containing hemoglobins
S and C and may contribute to the abnormal dehydration state of these cells. Human K: Cl-
CT (gene product KCC1) has been recently sequenced from human (hKCC1), rabbit and rat
tissue by Gillenet al.(J Biol Chem 271: 16237, 1996). We report here the sequence of KCC1
from human and mouse erythroleukemic cells (K562 and MEL cells, respectively). The cDNA …
(K: Cl-CT). The activity of K: Cl-CT is increased in pathologic RBCs containing hemoglobins
S and C and may contribute to the abnormal dehydration state of these cells. Human K: Cl-
CT (gene product KCC1) has been recently sequenced from human (hKCC1), rabbit and rat
tissue by Gillenet al.(J Biol Chem 271: 16237, 1996). We report here the sequence of KCC1
from human and mouse erythroleukemic cells (K562 and MEL cells, respectively). The cDNA …
