Expanded cohorts of maternal CD8+ T-cells specific for paternal MHC class I accumulate during pregnancy
M Zhou, AL Mellor - Journal of reproductive immunology, 1998 - Elsevier
A recombinant H-2Kb transgene, GK, containing the human HLA-G gene promoter is
expressed throughout the trophoblast when inherited paternally. Male GK transgenic mice
were mated with female T-cell receptor (TCR) transgenic mice to assess the effect of fetal H-
2Kb expression on maternal H-2Kb-specific CD8+ T-cells during pregnancy. The number of
maternal H-2Kb-specific CD8+ T-cells in spleen increased significantly (∼ 3-fold) 10 days
post coitus when the GK transgene was inherited from the father. A smaller (∼ 2-fold) …
expressed throughout the trophoblast when inherited paternally. Male GK transgenic mice
were mated with female T-cell receptor (TCR) transgenic mice to assess the effect of fetal H-
2Kb expression on maternal H-2Kb-specific CD8+ T-cells during pregnancy. The number of
maternal H-2Kb-specific CD8+ T-cells in spleen increased significantly (∼ 3-fold) 10 days
post coitus when the GK transgene was inherited from the father. A smaller (∼ 2-fold) …
