[HTML][HTML] CD8 T cells can reject major histocompatibility complex class I-deficient skin allografts
C He, PS Heeger - American Journal of Transplantation, 2004 - Elsevier
Following transplantation, recipient T cells can recognize and respond to donor antigens
expressed directly on donor cells, and can respond to donor-derived peptides that have
been processed and presented in the context of recipient MHC through the indirect pathway.
Indirectly primed CD4+ T cells have been well studied in transplantation, but little
information is available regarding whether indirectly primed CD8+ T cells participate in
rejection. To address this, we placed MHC class I-deficient D b K b knockout skin grafts onto …
expressed directly on donor cells, and can respond to donor-derived peptides that have
been processed and presented in the context of recipient MHC through the indirect pathway.
Indirectly primed CD4+ T cells have been well studied in transplantation, but little
information is available regarding whether indirectly primed CD8+ T cells participate in
rejection. To address this, we placed MHC class I-deficient D b K b knockout skin grafts onto …
