Estimating the contribution of genes and environment to variation in renal drug clearance
MK Leabman, KM Giacomini - Pharmacogenetics and Genomics, 2003 - journals.lww.com
Renal excretion is the major pathway for elimination of many clinically used drugs and
xenobiotics. We estimated the genetic component (r GC) contributing to variation in renal
clearance for six compounds (amoxicillin, ampicillin, metformin, terodiline, digoxin and
iohexol) using Repeated Drug Application methodology. Data were obtained from published
literature. The r GC values of renal clearance of metformin, amoxicillin, and ampicillin, which
undergo transporter-mediated secretion, ranged from 0.64–0.94. This finding suggests that …
xenobiotics. We estimated the genetic component (r GC) contributing to variation in renal
clearance for six compounds (amoxicillin, ampicillin, metformin, terodiline, digoxin and
iohexol) using Repeated Drug Application methodology. Data were obtained from published
literature. The r GC values of renal clearance of metformin, amoxicillin, and ampicillin, which
undergo transporter-mediated secretion, ranged from 0.64–0.94. This finding suggests that …