[HTML][HTML] Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative α2 subunit of AMP-activated protein kinase
Y Xing, N Musi, N Fujii, L Zou, I Luptak… - Journal of Biological …, 2003 - ASBMB
AMP-activated protein kinase (AMPK) is an energy-sensing enzyme that plays a pivotal role
in regulating cellular metabolism for sustaining energy homeostasis under stress conditions.
Activation of AMPK has been observed in the heart during acute and chronic stresses, but its
functional role has not been completely understood because of the lack of effective
activators and inhibitors of this kinase in the heart. We generated transgenic mice (TG) with
cardiac-specific overexpression of a dominant negative mutant of the AMPK α2 catalytic …
in regulating cellular metabolism for sustaining energy homeostasis under stress conditions.
Activation of AMPK has been observed in the heart during acute and chronic stresses, but its
functional role has not been completely understood because of the lack of effective
activators and inhibitors of this kinase in the heart. We generated transgenic mice (TG) with
cardiac-specific overexpression of a dominant negative mutant of the AMPK α2 catalytic …
