Expression of T cell immunoglobulin-and mucin-domain-containing molecules-1 and-3 (TIM-1 and-3) in the rat nervous and immune systems
Expression of T cell immunoglobulin-and mucin-domain-containing molecules (TIMs) can be
used as T helper (Th) differentiation markers in the human and mouse. We examined the
expression of TIM-1 and-3 mRNAs in rat MBP63–88-induced experimental autoimmune
encephalomyelitis (EAE). TIM-3 expression was upregulated in the spinal cord during EAE
and following antigen restimulation of the encephalitogenic TCRBV8S2+ population.
Interestingly, TIM-3 expression was also detected by in situ hybridization in resident cells of …
used as T helper (Th) differentiation markers in the human and mouse. We examined the
expression of TIM-1 and-3 mRNAs in rat MBP63–88-induced experimental autoimmune
encephalomyelitis (EAE). TIM-3 expression was upregulated in the spinal cord during EAE
and following antigen restimulation of the encephalitogenic TCRBV8S2+ population.
Interestingly, TIM-3 expression was also detected by in situ hybridization in resident cells of …
