[HTML][HTML] Plasticity of T cell memory responses to viruses

LK Selin, RM Welsh - Immunity, 2004 - cell.com
Immunity, 2004cell.com
Virus-specific memory T cell populations demonstrate plasticity in antigenic and functional
phenotype, in recognition of antigen, and in their ability to accommodate new memory T cell
populations. The adaptability of complex antigen-specific T cell repertoires allows the host to
respond to a diverse array of pathogens and accommodate memory pools to many
pathogens in a finite immune system. This is in part accounted for by crossreactive memory
T cells, which can be employed in immune responses and mediate protective immunity or …
Abstract
Virus-specific memory T cell populations demonstrate plasticity in antigenic and functional phenotype, in recognition of antigen, and in their ability to accommodate new memory T cell populations. The adaptability of complex antigen-specific T cell repertoires allows the host to respond to a diverse array of pathogens and accommodate memory pools to many pathogens in a finite immune system. This is in part accounted for by crossreactive memory T cells, which can be employed in immune responses and mediate protective immunity or life-threatening immunopathology.
cell.com