Checkpoint signalling: focusing on 53BP1
RT Abraham - Nature cell biology, 2002 - nature.com
Nature cell biology, 2002•nature.com
The p53-binding protein 53BP1 has been implicated in DNA damage responses. Three new
reports indicate that 53BP1 is central to both the S and G2 checkpoints after exposure to
ionizing radiation (IR). 53BP1 participates in the organization of nuclear foci and facilitates
the phosphorylation of specific substrates by the checkpoint kinase, ataxia-telangiectasia
mutated (ATM).
reports indicate that 53BP1 is central to both the S and G2 checkpoints after exposure to
ionizing radiation (IR). 53BP1 participates in the organization of nuclear foci and facilitates
the phosphorylation of specific substrates by the checkpoint kinase, ataxia-telangiectasia
mutated (ATM).
The p53-binding protein 53BP1 has been implicated in DNA damage responses. Three new reports indicate that 53BP1 is central to both the S and G2 checkpoints after exposure to ionizing radiation (IR). 53BP1 participates in the organization of nuclear foci and facilitates the phosphorylation of specific substrates by the checkpoint kinase, ataxia-telangiectasia mutated (ATM).
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