[HTML][HTML] AP-2-dependent internalization of potassium channel Kir2. 3 is driven by a novel di-hydrophobic signal
AK Mason, BE Jacobs, PA Welling - Journal of biological chemistry, 2008 - ASBMB
The localization and density of Kir2. 3 channels are influenced by the balance between PDZ
protein interaction at the cell surface and routing into the endocytic pathway. Here, we
explore mechanisms by which the Kir2. 3 channel is directed into the endocytic pathway. We
found that Kir2. 3 channels are constitutively internalized from the cell surface in a dynamin-
dependent manner, indicative of vesicle-mediated endocytosis. The rate of Kir2. 3
endocytosis was dramatically attenuated following RNA interference-mediated knockdown …
protein interaction at the cell surface and routing into the endocytic pathway. Here, we
explore mechanisms by which the Kir2. 3 channel is directed into the endocytic pathway. We
found that Kir2. 3 channels are constitutively internalized from the cell surface in a dynamin-
dependent manner, indicative of vesicle-mediated endocytosis. The rate of Kir2. 3
endocytosis was dramatically attenuated following RNA interference-mediated knockdown …
