[PDF][PDF] Double antiangiogenic protein, DAAP, targeting VEGF-A and angiopoietins in tumor angiogenesis, metastasis, and vascular leakage
Cancer cell, 2010•cell.com
Two vascular growth factor families, VEGF and the angiopoietins, play critical and
coordinate roles in tumor progression and metastasis. A single inhibitor targeting both VEGF
and angiopoietins is not available. Here, we developed a chimeric decoy receptor, namely
double anti-angiogenic protein (DAAP), which can simultaneously bind VEGF-A and
angiopoietins, blocking their actions. Compared to VEGF-Trap or Tie2-Fc, which block either
VEGF-A or angiopoietins alone, we believe DAAP is a highly effective molecule for …
coordinate roles in tumor progression and metastasis. A single inhibitor targeting both VEGF
and angiopoietins is not available. Here, we developed a chimeric decoy receptor, namely
double anti-angiogenic protein (DAAP), which can simultaneously bind VEGF-A and
angiopoietins, blocking their actions. Compared to VEGF-Trap or Tie2-Fc, which block either
VEGF-A or angiopoietins alone, we believe DAAP is a highly effective molecule for …
Summary
Two vascular growth factor families, VEGF and the angiopoietins, play critical and coordinate roles in tumor progression and metastasis. A single inhibitor targeting both VEGF and angiopoietins is not available. Here, we developed a chimeric decoy receptor, namely double anti-angiogenic protein (DAAP), which can simultaneously bind VEGF-A and angiopoietins, blocking their actions. Compared to VEGF-Trap or Tie2-Fc, which block either VEGF-A or angiopoietins alone, we believe DAAP is a highly effective molecule for regressing tumor angiogenesis and metastasis in implanted and spontaneous solid tumors; it can also effectively reduce ascites formation and vascular leakage in an ovarian carcinoma model. Thus, simultaneous blockade of VEGF-A and angiopoietins with DAAP is an effective therapeutic strategy for blocking tumor angiogenesis, metastasis, and vascular leakage.
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