[HTML][HTML] Endogenous proteolytic cleavage of disease-associated prion protein to produce C2 fragments is strongly cell-and tissue-dependent
M Dron, M Moudjou, J Chapuis, MKF Salamat… - Journal of biological …, 2010 - ASBMB
The abnormally folded form of the prion protein (PrP Sc) accumulating in nervous and
lymphoid tissues of prion-infected individuals can be naturally cleaved to generate a N-
terminal-truncated fragment called C2. Information about the identity of the cellular
proteases involved in this process and its possible role in prion biology has remained limited
and controversial. We investigated PrP Sc N-terminal trimming in different cell lines and
primary cultured nerve cells, and in the brain and spleen tissue from transgenic mice …
lymphoid tissues of prion-infected individuals can be naturally cleaved to generate a N-
terminal-truncated fragment called C2. Information about the identity of the cellular
proteases involved in this process and its possible role in prion biology has remained limited
and controversial. We investigated PrP Sc N-terminal trimming in different cell lines and
primary cultured nerve cells, and in the brain and spleen tissue from transgenic mice …