RAF inhibition and induction of cutaneous squamous cell carcinoma
C Robert, JP Arnault, C Mateus - Current opinion in oncology, 2011 - journals.lww.com
C Robert, JP Arnault, C Mateus
Current opinion in oncology, 2011•journals.lww.comThis review discusses the various mechanisms that could be implicated in the appearance
of skin tumors during the course of anti-RAF treatments as well as the implications of these
findings for clinical practice and future drug development. The unexpected emergence of
tumors during the course of anticancer therapies is a concern that stimulates an active field
of research in the aim of understanding the underlying mechanisms and preventing if
possible skin tumor initiation.
of skin tumors during the course of anti-RAF treatments as well as the implications of these
findings for clinical practice and future drug development. The unexpected emergence of
tumors during the course of anticancer therapies is a concern that stimulates an active field
of research in the aim of understanding the underlying mechanisms and preventing if
possible skin tumor initiation.
Summary
This review discusses the various mechanisms that could be implicated in the appearance of skin tumors during the course of anti-RAF treatments as well as the implications of these findings for clinical practice and future drug development. The unexpected emergence of tumors during the course of anticancer therapies is a concern that stimulates an active field of research in the aim of understanding the underlying mechanisms and preventing if possible skin tumor initiation.
Lippincott Williams & Wilkins