Immunoglobulin and complement deposits in nerves of patients with chronic relapsing polyneuropathy
MC Dalakas, WK Engel - Archives of neurology, 1980 - jamanetwork.com
• Sural nerve biopsy specimens from seven patients with chronic relapsing polyneuropathy
(CRP) were studied by direct immunofluorescence. Granular deposits containing IgM (7/7)
and C 3 (6/7)(and occasionally IgG, 3/7) were found in intraneural blood vessels. Linear
deposits of IgM (6/7)(and occasionally IgG, 3/7) without C 3 (0/7) were found on the
Schwann cell plasmalemma (and sometimes extending deeper into the Schwann cell) of yet
undemyelinated portions of nerve fibers. Albumin and fibrinogen were not found in any …
(CRP) were studied by direct immunofluorescence. Granular deposits containing IgM (7/7)
and C 3 (6/7)(and occasionally IgG, 3/7) were found in intraneural blood vessels. Linear
deposits of IgM (6/7)(and occasionally IgG, 3/7) without C 3 (0/7) were found on the
Schwann cell plasmalemma (and sometimes extending deeper into the Schwann cell) of yet
undemyelinated portions of nerve fibers. Albumin and fibrinogen were not found in any …
