Mechanisms and consequences of salt sensitivity and dietary salt intake
Current opinion in nephrology and hypertension, 2011•journals.lww.com
There is growing appreciation that, independently of alterations in blood pressure, dietary
intake of sodium and potassium promotes functional changes in the vasculature and
lymphatic system. These changes may protect against development of salt-sensitive
hypertension. While salt sensitivity cannot be ascribed exclusively to these factors,
perturbation of these processes promotes hypertension during high-salt intake. These
studies add to the list of genetic and environmental factors that are associated with salt …
intake of sodium and potassium promotes functional changes in the vasculature and
lymphatic system. These changes may protect against development of salt-sensitive
hypertension. While salt sensitivity cannot be ascribed exclusively to these factors,
perturbation of these processes promotes hypertension during high-salt intake. These
studies add to the list of genetic and environmental factors that are associated with salt …
Summary
There is growing appreciation that, independently of alterations in blood pressure, dietary intake of sodium and potassium promotes functional changes in the vasculature and lymphatic system. These changes may protect against development of salt-sensitive hypertension. While salt sensitivity cannot be ascribed exclusively to these factors, perturbation of these processes promotes hypertension during high-salt intake. These studies add to the list of genetic and environmental factors that are associated with salt sensitivity, but in particular provide insight into adaptive mechanisms during high salt intake.
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