Asymmetric germ cell division and oocyte determination during Drosophila oogenesis

W Deng, H Lin - International review of cytology, 2001 - Elsevier
Early oogenesis in Drosophila, with a stereotypic pattern of germ cell division and
differentiation, provides an attractive model for studying cell lineage and patterning.
Drosophila oogenesis is initiated when a germline stem cell divides asymmetrically to
produce a daughter stem cell and a cytoblast. The cystoblast then undergoes four rounds of
incomplete mitoses to form a 16-cell cyst, accompanied by the formation of the fusome.
Within the cyst, one of the two cells with four intercellular bridges differentiates into an oocyte …