[PDF][PDF] Islet amyloid and fibrosis in the cardiometabolic syndrome and type 2 diabetes mellitus
MR Hayden - Journal of the Cardiometabolic Syndrome, 2007 - researchgate.net
MR Hayden
Journal of the Cardiometabolic Syndrome, 2007•researchgate.netIslet Amyloid and Fibrosis in the Cardiometabolic Syndrome and Type 2 Diabetes Mellitus
Page 1 islet amyloid & fibrosis JCMS winter 2007 70 Type 2 diabetes mellitus (T2DM) is a
chronic multifactorial disease characterized by insulin resistance and β-cell dysfunction with
progression to eventual β-cell failure. It has both polygenic and environmental (overnutrition
and underexercise) etiologies deeply rooted within the cardiometabolic syndrome (CMS).
T2DM is closely associated with an atherogenic dyslipidemia, obesity, and insulin resistance …
Page 1 islet amyloid & fibrosis JCMS winter 2007 70 Type 2 diabetes mellitus (T2DM) is a
chronic multifactorial disease characterized by insulin resistance and β-cell dysfunction with
progression to eventual β-cell failure. It has both polygenic and environmental (overnutrition
and underexercise) etiologies deeply rooted within the cardiometabolic syndrome (CMS).
T2DM is closely associated with an atherogenic dyslipidemia, obesity, and insulin resistance …
Discussion
Because routine H&E staining of pancreatic islets may not reveal any discernible abnormalities at autopsy, specialized staining procedures were used in an attempt to better understand the histologic islet abnormalities in this patient (Figure 1, panels A and B).
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