[HTML][HTML] Differential activation of innate immune pathways by distinct islet amyloid polypeptide (IAPP) aggregates
Aggregation of islet amyloid polypeptide (IAPP) contributes to beta cell dysfunction in type 2
diabetes and islet transplantation. Like other amyloidogenic peptides, human IAPP induces
macrophage IL-1β secretion by stimulating both the synthesis and processing of proIL-1β, a
pro-inflammatory cytokine that (when chronically elevated) impairs beta cell insulin
secretion. We sought to determine the specific mechanism of IAPP-induced proIL-1β
synthesis. Soluble IAPP species produced early during IAPP aggregation provided a Toll …
diabetes and islet transplantation. Like other amyloidogenic peptides, human IAPP induces
macrophage IL-1β secretion by stimulating both the synthesis and processing of proIL-1β, a
pro-inflammatory cytokine that (when chronically elevated) impairs beta cell insulin
secretion. We sought to determine the specific mechanism of IAPP-induced proIL-1β
synthesis. Soluble IAPP species produced early during IAPP aggregation provided a Toll …