Random monoallelic expression: regulating gene expression one allele at a time
MA Eckersley-Maslin, DL Spector - Trends in Genetics, 2014 - cell.com
Trends in Genetics, 2014•cell.com
Monoallelic gene expression is a remarkable process in which transcription occurs from only
one of two homologous alleles in a diploid cell. Interestingly, between 0.5% and 15% of
autosomal genes exhibit random monoallelic gene expression, in which different cells
express only one allele independently of the underlying genomic sequence, in a cell type-
specific manner. Recently, genome-wide studies have increased our understanding of the
cell type-specific incidence of random monoallelic gene expression, and how the imbalance …
one of two homologous alleles in a diploid cell. Interestingly, between 0.5% and 15% of
autosomal genes exhibit random monoallelic gene expression, in which different cells
express only one allele independently of the underlying genomic sequence, in a cell type-
specific manner. Recently, genome-wide studies have increased our understanding of the
cell type-specific incidence of random monoallelic gene expression, and how the imbalance …
Monoallelic gene expression is a remarkable process in which transcription occurs from only one of two homologous alleles in a diploid cell. Interestingly, between 0.5% and 15% of autosomal genes exhibit random monoallelic gene expression, in which different cells express only one allele independently of the underlying genomic sequence, in a cell type-specific manner. Recently, genome-wide studies have increased our understanding of the cell type-specific incidence of random monoallelic gene expression, and how the imbalance in allelic expression is distinguished within the cell and potentially maintained across cell generations. Monoallelic gene expression is likely generated through stochastic independent regulation of the two alleles upon differentiation, and has varied implications for the cell and organism, in particular with respect to disease.
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