[HTML][HTML] Akt participation in the Wnt signaling pathway through Dishevelled
Inactivation of glycogen synthase kinase 3β (GSK3β) and the resulting stabilization of free β-
catenin are critical steps in the activation of Wnt target genes. While Akt regulates GSK3α/β
in the phosphatidylinositide 3-OH kinase signaling pathway, its role in Wnt signaling is
unknown. Here we report that expression of Wnt or Dishevelled (Dvl) increased Akt activity.
Activated Akt bound to the Axin-GSK3β complex in the presence of Dvl, phosphorylated
GSK3β and increased free β-catenin levels. Furthermore, in Wnt-overexpressing PC12 cells …
catenin are critical steps in the activation of Wnt target genes. While Akt regulates GSK3α/β
in the phosphatidylinositide 3-OH kinase signaling pathway, its role in Wnt signaling is
unknown. Here we report that expression of Wnt or Dishevelled (Dvl) increased Akt activity.
Activated Akt bound to the Axin-GSK3β complex in the presence of Dvl, phosphorylated
GSK3β and increased free β-catenin levels. Furthermore, in Wnt-overexpressing PC12 cells …