[HTML][HTML] Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia
MLL1, located on human chromosome 11, is disrupted in distinct recurrent chromosomal
translocations in several leukemia subsets. Studying the MLL1 gene and its oncogenic
variants has provided a paradigm for understanding cancer initiation and maintenance
through aberrant epigenetic gene regulation. Here we review the historical development of
model systems to recapitulate oncogenic MLL1-rearrangement (MLL-r) alleles encoding
mixed-lineage leukemia fusion proteins (MLL-FPs) or internal gene rearrangement products …
translocations in several leukemia subsets. Studying the MLL1 gene and its oncogenic
variants has provided a paradigm for understanding cancer initiation and maintenance
through aberrant epigenetic gene regulation. Here we review the historical development of
model systems to recapitulate oncogenic MLL1-rearrangement (MLL-r) alleles encoding
mixed-lineage leukemia fusion proteins (MLL-FPs) or internal gene rearrangement products …