Immunosuppression in elderly recipients has been underappreciated in clinical trials. Here,
we assessed age-specific effects of the calcineurin inhibitor tacrolimus (TAC) in a murine
transplant model and assessed its clinical relevance on human T cells. Old recipient mice
exhibited prolonged skin graft survival compared with young animals after TAC
administration. More important, half of the TAC dose was sufficient in old mice to achieve
comparable systemic trough levels. TAC administration was able to reduce proinflammatory …