[HTML][HTML] Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2

DJ Riese, T Komurasaki, GD Plowman… - Journal of Biological …, 1998 - ASBMB
Epiregulin (EPR) is a recently described member of the epidermal growth factor (EGF) family
of peptide growth factors. The ever expanding size of the EGF family has made
distinguishing the activities of these hormones paramount. We show here that EPR activates
two members of the ErbB family of receptor tyrosine kinases, epidermal growth factor
receptor (EGFR) and ErbB4. Therefore by these criteria, EPR is qualitatively similar to
another EGF family hormone, betacellulin (BTC). Yet, here we also demonstrate quantitative …