Lipid and metabolic syndrome traits in coronary artery disease: a Mendelian randomization study
DG Thomas, Y Wei, AR Tall - Journal of lipid research, 2021 - ASBMB
Mendelian randomization (MR) of lipid traits in CAD has provided evidence for causal
associations of LDL-C and TGs in CAD, but many lipid trait genetic variants have pleiotropic
effects on other cardiovascular risk factors that may bias MR associations. The goal of this
study was to evaluate pleiotropic effects of lipid trait genetic variants and to account for these
effects in MR of lipid traits in CAD. We performed multivariable MR using inverse variance-
weighted and MR-Egger methods in large (n≥ 300,000) GWAS datasets. We found that …
associations of LDL-C and TGs in CAD, but many lipid trait genetic variants have pleiotropic
effects on other cardiovascular risk factors that may bias MR associations. The goal of this
study was to evaluate pleiotropic effects of lipid trait genetic variants and to account for these
effects in MR of lipid traits in CAD. We performed multivariable MR using inverse variance-
weighted and MR-Egger methods in large (n≥ 300,000) GWAS datasets. We found that …
