Tissue angiotensin II (Angll) is increased in the infarcted rat heart, where it may have
autocrine or paracrine properties that influence cellular protein synthesis and growth and
therefore tissue repair. It was our hypothesis that treatment with an AT1 receptor antagonist
would attenuate fibrous tissue formation after myocardial infarction (MI). To investigate a role
for local Angll in the regulation of connective tissue formation during early and late wound
healing that follows MI, this study was undertaken. Animals were randomized into two …