Syphilis is a human infection of global importance. Its diagnosis can be challenging,
requiring construction of a serologic profile based on the results of at least two types of
antibody tests: treponemal and nontreponemal. The traditional approach to the
serodiagnosis of syphilis has been the use of a nontreponemal screening assay followed by
the performance of a treponemal confirmatory test if the initial nontreponemal screening test
was reactive. With the increasing availability of automated, easier-to-perform, and rapid …