Facile room temperature synthesis of fluorine-18 labeled fluoronicotinic acid-2, 3, 5, 6-tetrafluorophenyl ester without azeotropic drying of fluorine-18
F Basuli, X Zhang, EM Jagoda, PL Choyke… - Nuclear medicine and …, 2016 - Elsevier
Abstract Fluorine-18 labeled fluoronicotinic acid-2, 3, 5, 6-tetrafluorophenyl ester has been
successfully synthesized in an unprecedented way by flowing an acetonitrile solution of its
quaternary ammonium salt precursor (N, N, N-trimethyl-5-((2, 3, 5, 6-tetrafluorophenoxy)
carbonyl) pyridin-2-aminium trifluoromethanesulfonate, 1) through an anion exchange
cartridge. The fluorination reaction proceeded at room temperature without azeotropic drying
of the fluoride. Over 75% conversion was observed with 10 mg of precursor in 2: 8 …
successfully synthesized in an unprecedented way by flowing an acetonitrile solution of its
quaternary ammonium salt precursor (N, N, N-trimethyl-5-((2, 3, 5, 6-tetrafluorophenoxy)
carbonyl) pyridin-2-aminium trifluoromethanesulfonate, 1) through an anion exchange
cartridge. The fluorination reaction proceeded at room temperature without azeotropic drying
of the fluoride. Over 75% conversion was observed with 10 mg of precursor in 2: 8 …