Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin

I Bergheim, S Weber, M Vos, S Krämer, V Volynets… - Journal of …, 2008 - Elsevier
BACKGROUND/AIMS: Consumption of refined carbohydrates in soft drinks has been
postulated to be a key factor in the development of non-alcoholic fatty liver disease (NAFLD).
The aim of the present study was to test the effects of ad libitum access to different sugars
consumed in drinking water on hepatic fat accumulation. METHODS: For 8 weeks, C57BL/J6
mice had free access to solutions containing 30% glucose, fructose, sucrose, or water
sweetened with artificial sweetener (AS) or plain water. Body weight, caloric intake, hepatic …