The mitochondrial‐derived peptide MOTS‐c: a player in exceptional longevity?
Aging cell, 2015•Wiley Online Library
Mitochondrial‐derived peptides (MDP) are encoded by functional short open reading frames
in the mitochondrial DNA (mt DNA). These include humanin, and the recently discovered
mitochondrial open reading frame of the 12S rRNA‐c (MOTS‐c). Although more research is
needed, we suggest that the m. 1382A> C polymorphism located in the MOTS‐c encoding
mt DNA, which is specific for the Northeast Asian population, may be among the putative
biological mechanisms explaining the high longevity of Japanese people.
in the mitochondrial DNA (mt DNA). These include humanin, and the recently discovered
mitochondrial open reading frame of the 12S rRNA‐c (MOTS‐c). Although more research is
needed, we suggest that the m. 1382A> C polymorphism located in the MOTS‐c encoding
mt DNA, which is specific for the Northeast Asian population, may be among the putative
biological mechanisms explaining the high longevity of Japanese people.
Summary
Mitochondrial‐derived peptides (MDP) are encoded by functional short open reading frames in the mitochondrial DNA (mtDNA). These include humanin, and the recently discovered mitochondrial open reading frame of the 12S rRNA‐c (MOTS‐c). Although more research is needed, we suggest that the m.1382A>C polymorphism located in the MOTS‐c encoding mtDNA, which is specific for the Northeast Asian population, may be among the putative biological mechanisms explaining the high longevity of Japanese people.
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