Sphingolipids (SLs) are essential constituents of eukaryotic cells. Besides playing structural
roles in cellular membranes, some metabolites, including ceramide, sphingosine, and
sphingosine-1-phosphate, have drawn attention as bioactive signaling molecules involved
in the regulation of cell growth, differentiation, senescence, and apoptosis. Understanding
the many cell regulatory functions of SL metabolites requires an advanced knowledge of
how and where in the cell they are generated, converted, or degraded. This review will …