[HTML][HTML] Maintenance of redox homeostasis by hypoxia-inducible factors
D Samanta, GL Semenza - Redox biology, 2017 - Elsevier
D Samanta, GL Semenza
Redox biology, 2017•ElsevierOxidative phosphorylation enables cells to generate the large amounts of ATP required for
development and maintenance of multicellular organisms. However, under conditions of
reduced O 2 availability, electron transport becomes less efficient, leading to increased
generation of superoxide anions. Hypoxia-inducible factors switch cells from oxidative to
glycolytic metabolism, to reduce mitochondrial superoxide generation, and increase the
synthesis of NADPH and glutathione, in order to maintain redox homeostasis under hypoxic …
development and maintenance of multicellular organisms. However, under conditions of
reduced O 2 availability, electron transport becomes less efficient, leading to increased
generation of superoxide anions. Hypoxia-inducible factors switch cells from oxidative to
glycolytic metabolism, to reduce mitochondrial superoxide generation, and increase the
synthesis of NADPH and glutathione, in order to maintain redox homeostasis under hypoxic …
Abstract
Oxidative phosphorylation enables cells to generate the large amounts of ATP required for development and maintenance of multicellular organisms. However, under conditions of reduced O2 availability, electron transport becomes less efficient, leading to increased generation of superoxide anions. Hypoxia-inducible factors switch cells from oxidative to glycolytic metabolism, to reduce mitochondrial superoxide generation, and increase the synthesis of NADPH and glutathione, in order to maintain redox homeostasis under hypoxic conditions.
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