Rapid clearance of Lyme disease spirochetes lacking OspC from skin
K Tilly, A Bestor, MW Jewett, P Rosa - Infection and immunity, 2007 - Am Soc Microbiol
K Tilly, A Bestor, MW Jewett, P Rosa
Infection and immunity, 2007•Am Soc MicrobiolWe previously demonstrated that Borrelia burgdorferi requires OspC to colonize a
mammalian host. To delineate this requirement, we analyzed the clearance of ospC mutant
spirochetes and found that they were eliminated within 48 h. We conclude that B. burgdorferi
uses OspC to resist innate host defenses immediately after transmission.
mammalian host. To delineate this requirement, we analyzed the clearance of ospC mutant
spirochetes and found that they were eliminated within 48 h. We conclude that B. burgdorferi
uses OspC to resist innate host defenses immediately after transmission.
Abstract
We previously demonstrated that Borrelia burgdorferi requires OspC to colonize a mammalian host. To delineate this requirement, we analyzed the clearance of ospC mutant spirochetes and found that they were eliminated within 48 h. We conclude that B. burgdorferi uses OspC to resist innate host defenses immediately after transmission.
American Society for Microbiology