Lumbo-sacral neural crest derivatives fate mapped with the aid of Wnt-1 promoter integrate but are not essential to kidney development
Neural crest (NC) cells may be involved in kidney organogenesis by providing inductive
signals and contributing to cells of the renal stroma. We show here that the lumbo-sacral NC
cells fate mapped with the aid of Wnt-1 promoter in the mouse migrate close to the
metanephros at the initiation of organogenesis but these cells remain superficial to the
condensed Pax2-expressing mesenchymal cells. NC-derived cells enter later into the kidney
proper from the midline region. The NC cells contribute also to development of the extra …
signals and contributing to cells of the renal stroma. We show here that the lumbo-sacral NC
cells fate mapped with the aid of Wnt-1 promoter in the mouse migrate close to the
metanephros at the initiation of organogenesis but these cells remain superficial to the
condensed Pax2-expressing mesenchymal cells. NC-derived cells enter later into the kidney
proper from the midline region. The NC cells contribute also to development of the extra …