[HTML][HTML] Catalytic mechanisms of Fe (II)-and 2-oxoglutarate-dependent oxygenases
S Martinez, RP Hausinger - Journal of Biological Chemistry, 2015 - ASBMB
Mononuclear non-heme Fe (II)-and 2-oxoglutarate (2OG)-dependent oxygenases comprise
a large family of enzymes that utilize an Fe (IV)-oxo intermediate to initiate diverse oxidative
transformations with important biological roles. Here, four of the major types of Fe (II)/2OG-
dependent reactions are detailed: hydroxylation, halogenation, ring formation, and
desaturation. In addition, an atypical epimerization reaction is described. Studies identifying
several key intermediates in catalysis are concisely summarized, and the proposed …
a large family of enzymes that utilize an Fe (IV)-oxo intermediate to initiate diverse oxidative
transformations with important biological roles. Here, four of the major types of Fe (II)/2OG-
dependent reactions are detailed: hydroxylation, halogenation, ring formation, and
desaturation. In addition, an atypical epimerization reaction is described. Studies identifying
several key intermediates in catalysis are concisely summarized, and the proposed …
