[HTML][HTML] Interaction between the PH and START domains of ceramide transfer protein competes with phosphatidylinositol 4-phosphate binding by the PH domain
De novo synthesis of the sphingolipid sphingomyelin requires non-vesicular transport of
ceramide from the endoplasmic reticulum to the Golgi by the multidomain protein ceramide
transfer protein (CERT). CERT's N-terminal pleckstrin homology (PH) domain targets it to the
Golgi by binding to phosphatidylinositol 4-phosphate (PtdIns (4) P) in the Golgi membrane,
whereas its C-terminal StAR-related lipid transfer domain (START) carries out ceramide
transfer. Hyperphosphorylation of a serine-rich motif immediately after the PH domain …
ceramide from the endoplasmic reticulum to the Golgi by the multidomain protein ceramide
transfer protein (CERT). CERT's N-terminal pleckstrin homology (PH) domain targets it to the
Golgi by binding to phosphatidylinositol 4-phosphate (PtdIns (4) P) in the Golgi membrane,
whereas its C-terminal StAR-related lipid transfer domain (START) carries out ceramide
transfer. Hyperphosphorylation of a serine-rich motif immediately after the PH domain …