[HTML][HTML] Structural basis for the Golgi association by the pleckstrin homology domain of the ceramide trafficking protein (CERT)
T Sugiki, K Takeuchi, T Yamaji, T Takano… - Journal of Biological …, 2012 - ASBMB
Ceramide transport from the endoplasmic reticulum to the Golgi apparatus is crucial in
sphingolipid biosynthesis, and the process relies on the ceramide trafficking protein (CERT),
which contains pleckstrin homology (PH) and StAR-related lipid transfer domains. The
CERT PH domain specifically recognizes phosphatidylinositol 4-monophosphate (PtdIns (4)
P), a characteristic phosphoinositide in the Golgi membrane, and is indispensable for the
endoplasmic reticulum-to-Golgi transport of ceramide by CERT. In this study, we determined …
sphingolipid biosynthesis, and the process relies on the ceramide trafficking protein (CERT),
which contains pleckstrin homology (PH) and StAR-related lipid transfer domains. The
CERT PH domain specifically recognizes phosphatidylinositol 4-monophosphate (PtdIns (4)
P), a characteristic phosphoinositide in the Golgi membrane, and is indispensable for the
endoplasmic reticulum-to-Golgi transport of ceramide by CERT. In this study, we determined …