[HTML][HTML] Changes in synaptic proteins precede neurodegeneration markers in preclinical Alzheimer's disease cerebrospinal fluid
A biomarker of synapse loss, an early event in Alzheimer's disease (AD) pathophysiology
that precedes neuronal death and symptom onset, would be a much-needed prognostic
biomarker. With direct access to the brain interstitial fluid, the cerebrospinal fluid (CSF) is a
potential source of synapse-derived proteins. In this study, we aimed to identify and validate
novel CSF biomarkers of synapse loss in AD. Discovery: Combining shotgun proteomics of
the CSF with an exhaustive search of the literature and public databases, we identified 251 …
that precedes neuronal death and symptom onset, would be a much-needed prognostic
biomarker. With direct access to the brain interstitial fluid, the cerebrospinal fluid (CSF) is a
potential source of synapse-derived proteins. In this study, we aimed to identify and validate
novel CSF biomarkers of synapse loss in AD. Discovery: Combining shotgun proteomics of
the CSF with an exhaustive search of the literature and public databases, we identified 251 …
