KIBRA is a novel substrate for protein kinase Cζ
K Büther, C Plaas, A Barnekow… - … and biophysical research …, 2004 - Elsevier
K Büther, C Plaas, A Barnekow, J Kremerskothen
Biochemical and biophysical research communications, 2004•ElsevierWW domain-containing proteins are found in all eukaryotic cells and they are involved in the
regulation of a wide variety of cellular functions. We recently identified the neuronal protein
KIBRA as novel member of this family of signal transducers. In this report, we describe the
identification of protein kinase C (PKC) ζ as a KIBRA-interacting protein. PKCζ is known to
play an important role in synaptic plasticity and memory formation but its specific targets are
not well known. Our studies presented here revealed that KIBRA is a novel substrate for …
regulation of a wide variety of cellular functions. We recently identified the neuronal protein
KIBRA as novel member of this family of signal transducers. In this report, we describe the
identification of protein kinase C (PKC) ζ as a KIBRA-interacting protein. PKCζ is known to
play an important role in synaptic plasticity and memory formation but its specific targets are
not well known. Our studies presented here revealed that KIBRA is a novel substrate for …
WW domain-containing proteins are found in all eukaryotic cells and they are involved in the regulation of a wide variety of cellular functions. We recently identified the neuronal protein KIBRA as novel member of this family of signal transducers. In this report, we describe the identification of protein kinase C (PKC) ζ as a KIBRA-interacting protein. PKCζ is known to play an important role in synaptic plasticity and memory formation but its specific targets are not well known. Our studies presented here revealed that KIBRA is a novel substrate for PKCζ and suggest that PKCζ phosphorylation may regulate the cellular function of KIBRA.
Elsevier
