CHOP-ASO ameliorates glomerular and tubular damage on top of ACE inhibition in diabetic kidney disease
K Shahzad, S Fatima, I Gadi, H Khawaja… - Journal of the …, 2021 - journals.lww.com
Background Maladaptive endoplasmic reticulum stress signaling in diabetic kidney disease
(DKD) is linked to increased glomerular and tubular expression of the cell-death–promoting
transcription factor C/EBP homologous protein (CHOP). Here, we determined whether
locked nucleic acid (LNA)–modified antisense oligonucleotides (ASOs) targeting CHOP
ameliorate experimental DKD. Methods We determined the efficacy of CHOP-ASO in the
early and late stages of experimental DKD (in 8-or 16-week-old db/db mice, respectively) …
(DKD) is linked to increased glomerular and tubular expression of the cell-death–promoting
transcription factor C/EBP homologous protein (CHOP). Here, we determined whether
locked nucleic acid (LNA)–modified antisense oligonucleotides (ASOs) targeting CHOP
ameliorate experimental DKD. Methods We determined the efficacy of CHOP-ASO in the
early and late stages of experimental DKD (in 8-or 16-week-old db/db mice, respectively) …