Janus kinase inhibition in the Aicardi–Goutières syndrome
A Vanderver, L Adang, F Gavazzi… - … England Journal of …, 2020 - Mass Medical Soc
New England Journal of Medicine, 2020•Mass Medical Soc
JAK Inhibition in the Aicardi–Goutières Syndrome Patients with the Aicardi–Goutières
syndrome, an autosomal recessive disorder that affects the central nervous system, immune
system, and skin, have severe neurodevelopmental abnormalities and abnormal signaling
in the interferon pathway. In patients in this study, Janus kinase inhibition decreased skin
manifestations and improved neurologic function.
syndrome, an autosomal recessive disorder that affects the central nervous system, immune
system, and skin, have severe neurodevelopmental abnormalities and abnormal signaling
in the interferon pathway. In patients in this study, Janus kinase inhibition decreased skin
manifestations and improved neurologic function.
JAK Inhibition in the Aicardi–Goutières Syndrome
Patients with the Aicardi–Goutières syndrome, an autosomal recessive disorder that affects the central nervous system, immune system, and skin, have severe neurodevelopmental abnormalities and abnormal signaling in the interferon pathway. In patients in this study, Janus kinase inhibition decreased skin manifestations and improved neurologic function.
The New England Journal Of Medicine