Cytokines are critical for normal cell growth and immunoregulation but also contribute to
growth of malignant cells and drive immune-mediated disease. A large subset of
immunoregulatory cytokines uses the type I and type II cytokine receptors and
pharmacological targeting of these cytokines/cytokines receptors has proven to be
efficacious in treating immune and inflammatory diseases. These receptors rely on Janus
family of kinases (Jaks) for signal transduction. Recently the first Jak inhibitor (jakinib) has …