Misactivation of Hedgehog signaling causes inherited and sporadic cancers
David R. Raleigh1,2 and Jeremy F. Reiter3
1Department of Radiation Oncology,
2Department of Neurological Surgery, and
3Department of Biochemistry and Biophysics, UCSF, San Francisco, California, USA.
Address correspondence to: Jeremy F. Reiter, Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, 555 Mission Bay Boulevard South, Smith Building, Room 384S, San Francisco, California 94158, USA. Phone: 415.502.8520; Email: jeremy.reiter@ucsf.edu.
Find articles by Raleigh, D. in: JCI | PubMed | Google Scholar
1Department of Radiation Oncology,
2Department of Neurological Surgery, and
3Department of Biochemistry and Biophysics, UCSF, San Francisco, California, USA.
Address correspondence to: Jeremy F. Reiter, Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, 555 Mission Bay Boulevard South, Smith Building, Room 384S, San Francisco, California 94158, USA. Phone: 415.502.8520; Email: jeremy.reiter@ucsf.edu.
Find articles by Reiter, J. in: JCI | PubMed | Google Scholar
First published February 1, 2019 - More info
J Clin Invest. 2019;129(2):465–475. https://doi.org/10.1172/JCI120850.
Copyright © 2019, American Society for Clinical Investigation
The Hedgehog pathway is critical for the development of diverse organs. Misactivation of the Hedgehog pathway can cause developmental abnormalities and cancers, including medulloblastoma, the most common pediatric brain tumor, and basal cell carcinoma, the most common cancer in the United States. Here, we review how basic, translational, and clinical studies of the Hedgehog pathway have helped reveal how cells communicate, how intercellular communication controls development, how signaling goes awry to cause cancer, and how to use targeted molecular agents to treat both inherited and sporadic cancers.
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