Review Series 10.1172/JCI129192
1Nutrition and Obesities: Systemic Approaches (NutriOmics, UMRS U1269), INSERM, Sorbonne Université, Paris, France.
2Immunometabolism, Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
3Nutrition Department, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de Paris, Paris, France.
Address correspondence to: Geneviève Marcelin or Karine Clément, UMR1269 – INSERM/Sorbonne Université, Faculté de médecine Pitié Salpêtrière, 91, Boulevard de l’hôpital, 75013 Paris, France. Phone: 01.40.77.96.74; Email: genevieve_marcelin@yahoo.fr (GM). Phone: 01.42.17.79.19; Email: karine.clement@inserm.fr (KC).
Authorship note: ALMS and LBM contributed equally to this work.
Find articles by Marcelin, G. in: JCI | PubMed | Google Scholar
1Nutrition and Obesities: Systemic Approaches (NutriOmics, UMRS U1269), INSERM, Sorbonne Université, Paris, France.
2Immunometabolism, Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
3Nutrition Department, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de Paris, Paris, France.
Address correspondence to: Geneviève Marcelin or Karine Clément, UMR1269 – INSERM/Sorbonne Université, Faculté de médecine Pitié Salpêtrière, 91, Boulevard de l’hôpital, 75013 Paris, France. Phone: 01.40.77.96.74; Email: genevieve_marcelin@yahoo.fr (GM). Phone: 01.42.17.79.19; Email: karine.clement@inserm.fr (KC).
Authorship note: ALMS and LBM contributed equally to this work.
Find articles by Silveira, A. in: JCI | PubMed | Google Scholar
1Nutrition and Obesities: Systemic Approaches (NutriOmics, UMRS U1269), INSERM, Sorbonne Université, Paris, France.
2Immunometabolism, Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
3Nutrition Department, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de Paris, Paris, France.
Address correspondence to: Geneviève Marcelin or Karine Clément, UMR1269 – INSERM/Sorbonne Université, Faculté de médecine Pitié Salpêtrière, 91, Boulevard de l’hôpital, 75013 Paris, France. Phone: 01.40.77.96.74; Email: genevieve_marcelin@yahoo.fr (GM). Phone: 01.42.17.79.19; Email: karine.clement@inserm.fr (KC).
Authorship note: ALMS and LBM contributed equally to this work.
Find articles by Martins, L. in: JCI | PubMed | Google Scholar
1Nutrition and Obesities: Systemic Approaches (NutriOmics, UMRS U1269), INSERM, Sorbonne Université, Paris, France.
2Immunometabolism, Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
3Nutrition Department, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de Paris, Paris, France.
Address correspondence to: Geneviève Marcelin or Karine Clément, UMR1269 – INSERM/Sorbonne Université, Faculté de médecine Pitié Salpêtrière, 91, Boulevard de l’hôpital, 75013 Paris, France. Phone: 01.40.77.96.74; Email: genevieve_marcelin@yahoo.fr (GM). Phone: 01.42.17.79.19; Email: karine.clement@inserm.fr (KC).
Authorship note: ALMS and LBM contributed equally to this work.
Find articles by Ferreira, A. in: JCI | PubMed | Google Scholar
1Nutrition and Obesities: Systemic Approaches (NutriOmics, UMRS U1269), INSERM, Sorbonne Université, Paris, France.
2Immunometabolism, Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
3Nutrition Department, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de Paris, Paris, France.
Address correspondence to: Geneviève Marcelin or Karine Clément, UMR1269 – INSERM/Sorbonne Université, Faculté de médecine Pitié Salpêtrière, 91, Boulevard de l’hôpital, 75013 Paris, France. Phone: 01.40.77.96.74; Email: genevieve_marcelin@yahoo.fr (GM). Phone: 01.42.17.79.19; Email: karine.clement@inserm.fr (KC).
Authorship note: ALMS and LBM contributed equally to this work.
Find articles by Clément, K. in: JCI | PubMed | Google Scholar
First published September 9, 2019 - More info
Obesity originates from an imbalance between caloric intake and energy expenditure that promotes adipose tissue expansion, which is necessary to buffer nutrient excess. Patients with higher visceral fat mass are at a higher risk of developing severe complications such as type 2 diabetes and cardiovascular and liver diseases. However, increased fat mass does not fully explain obesity’s propensity to promote metabolic diseases. With chronic obesity, adipose tissue undergoes major remodeling, which can ultimately result in unresolved chronic inflammation leading to fibrosis accumulation. These features drive local tissue damage and initiate and/or maintain multiorgan dysfunction. Here, we review the current understanding of adipose tissue remodeling with a focus on obesity-induced adipose tissue fibrosis and its relevance to clinical manifestations.
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